abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

journal_title：Journal of neuroimmunology

authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

更新日期：2006-08-01 00:00:00

abstract：:The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after...

journal_title：Journal of neuroimmunology

authors： Veber D,Mutti E,Galmozzi E,Cedrola S,Galbiati S,Morabito A,Tredici G,La Porta CA,Scalabrino G

更新日期：2006-07-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

journal_title：Journal of neuroimmunology

authors： Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

更新日期：2006-07-01 00:00:00

abstract：:The objective of this study was to evaluate multiple interferon (IFN) specific mRNA biomarkers in multiple sclerosis (MS) patients with anti-IFN-beta neutralizing antibodies (NAB) using a pharmacodynamic study design. Thirty patients were enrolled. Blood samples were drawn at pre-treatment, 4-, 8-h time points followi...

journal_title：Journal of neuroimmunology

authors： Santos R,Weinstock-Guttman B,Tamaño-Blanco M,Badgett D,Zivadinov R,Justinger T,Munschauer F 3rd,Ramanathan M

更新日期：2006-07-01 00:00:00

abstract：:IFN-gamma (IFN-gamma) has been shown to activate astrocytes to acquire immune functions. In this study the effect of IFN-gamma on murine astrocytes was investigated via microarray analysis. The activating effect of IFN-gamma on the astrocyte transcriptome showed predominance toward pathways involved in adaptive immuni...

journal_title：Journal of neuroimmunology

authors： Halonen SK,Woods T,McInnerney K,Weiss LM

更新日期：2006-06-01 00:00:00

abstract：:We simultaneously measured 16 cytokines/chemokines in cerebrospinal fluid (CSF) from 14 patients with acute disseminated encephalomyelitis (ADEM) and 20 controls using a fluorescent bead-based immunoassay. A variety of cytokines, such as IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFN-gamma, TNF-alpha, G-CSF and MI...

journal_title：Journal of neuroimmunology

authors： Ishizu T,Minohara M,Ichiyama T,Kira R,Tanaka M,Osoegawa M,Hara T,Furukawa S,Kira J

更新日期：2006-06-01 00:00:00

abstract：:A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the...

journal_title：Journal of neuroimmunology

authors： Fu YF,Zhu YN,Ni J,Zhong XG,Tang W,Zhou R,Zhou Y,Dong JR,He PL,Wan H,Li YC,Yang YF,Zuo JP

更新日期：2006-06-01 00:00:00

abstract：:We have shown earlier that induction of experimental autoimmune encephalomyelitis (EAE)-a model for the human disease multiple sclerosis-in C57BL/6 wild-type mice resulted in the expression of the p75 low-affinity neurotrophin receptor (p75NTR) in endothelial cells in the CNS. In comparison to the clinical manifestati...

journal_title：Journal of neuroimmunology

authors： Küst B,Mantingh-Otter I,Boddeke E,Copray S

更新日期：2006-05-01 00:00:00

abstract：:Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, I...

journal_title：Journal of neuroimmunology

authors： Khalil M,Reindl M,Lutterotti A,Kuenz B,Ehling R,Gneiss C,Lackner P,Deisenhammer F,Berger T

更新日期：2006-05-01 00:00:00

abstract：:Autologous stem cell transplantation is being considered as treatment of severe refractory autoimmune disorders, including MS. Stem cell mobilization is achieved with granulocyte-colony stimulating factor (G-CSF), however, G-CSF administration resulted in cases of worsened clinical MS status. We studied autoreactive T...

journal_title：Journal of neuroimmunology

authors： Snir O,Lavie G,Achiron A,Bank I,Ben-Aharon T,Sredni B,Cohen IR,Mandel M

更新日期：2006-03-01 00:00:00

abstract：:The immunosuppressive nature of glucocorticoids has been well documented both in vitro and in vivo. This glucocorticoid-mediated immunosuppression has also been observed in immune cells within the central nervous system (CNS). For example, microglia have previously been shown to exhibit decreased proliferation, cytoki...

journal_title：Journal of neuroimmunology

authors： Nair A,Bonneau RH

更新日期：2006-02-01 00:00:00

abstract：:Inflammatory mediators have been proposed to play a critical role in the pathogenesis of choroidal neovascularization, a blinding complication of age-related macular degeneration. We evaluated the expression of TNF-alpha in human choroidal neovascular membranes and found that it colocalized with cells expressing VEGF,...

journal_title：Journal of neuroimmunology

authors： Hangai M,He S,Hoffmann S,Lim JI,Ryan SJ,Hinton DR

更新日期：2006-02-01 00:00:00

abstract：:We have investigated the efficacy of immunization against peptides from predisposing MHC class II molecules in human-compatible adjuvants for ameliorating experimental autoimmune myasthenia gravis (EAMG). C57BL/6 mice were immunized three times with the peptide I-Abetab62-76 in Alum+killed pertussis organisms (PT) pri...

journal_title：Journal of neuroimmunology

authors： Oshima M,Maruta T,Ohtani M,Deitiker PR,Mosier D,Atassi MZ

更新日期：2006-02-01 00:00:00

abstract：:To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), myelin oligodendrocyt...

journal_title：Journal of neuroimmunology

authors： Yentür SP,Gürses C,Demirbilek V,Yilmaz G,Onal AE,Yapici Z,Yalçinkaya C,Cokar O,Gökyiğit A,Saruhan-Direskeneli G

更新日期：2005-12-30 00:00:00

abstract：BACKGROUND:Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS. METHODS:MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and ...

journal_title：Journal of neuroimmunology

authors： Monteiro de Almeida S,Letendre S,Zimmerman J,Lazzaretto D,McCutchan A,Ellis R

更新日期：2005-12-01 00:00:00

abstract：:An appropriate inflammatory response is crucial for the maintenance of tissue homeostasis. The inflammatory responses seen in the brain parenchyma differ from those elicited in the periphery, ventricles and meninges. However, although an inflammatory component has been associated with many CNS diseases, the difference...

journal_title：Journal of neuroimmunology

authors： Depino A,Ferrari C,Pott Godoy MC,Tarelli R,Pitossi FJ

更新日期：2005-11-01 00:00:00

abstract：:EAN induced in Lewis rats by immunization with peripheral bovine myelin was treated by the Ras inhibitor farnesylthiosalicylate (FTS). Treatment from day 0 with FTS (5 mg/kg intraperitoneally twice daily) attenuated peak clinical scores (mean+/-S.E., 2.5+/-0.5 compared to 4.1+/-0.5 in saline treated controls, p=0.018,...

journal_title：Journal of neuroimmunology

authors： Kafri M,Kloog Y,Korczyn AD,Ferdman-Aronovich R,Drory V,Katzav A,Wirguin I,Chapman J

更新日期：2005-11-01 00:00:00

abstract：:TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of...

journal_title：Journal of neuroimmunology

authors： Letiembre M,Echchannaoui H,Ferracin F,Rivest S,Landmann R

更新日期：2005-11-01 00:00:00

abstract：:Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which i...

journal_title：Journal of neuroimmunology

authors： Dörr J,Roth K,Zurbuchen U,Deisz R,Bechmann I,Lehmann TN,Meier S,Nitsch R,Zipp F

更新日期：2005-10-01 00:00:00

abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

journal_title：Journal of neuroimmunology

authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

更新日期：2005-10-01 00:00:00

abstract：:Neurodegeneration following inflammatory injury is considered to be a pathological correlate of irreversible disability in patients with multiple sclerosis. The availability of neurotrophins could influence the probability or rate of disease progression and the time of onset. The BDNF-Val66Met-polymorphism leads to al...

journal_title：Journal of neuroimmunology

authors： Lindquist S,Schott BH,Ban M,Compston DA,Sawcer S,Sailer M

更新日期：2005-10-01 00:00:00

abstract：:Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS ...

journal_title：Journal of neuroimmunology

authors： Furlan R,Rovaris M,Martinelli Boneschi F,Khademi M,Bergami A,Gironi M,Deleidi M,Agosta F,Franciotta D,Scarpini E,Uccelli A,Zaffaroni M,Kurne A,Comi G,Olsson T,Filippi M,Martino G

更新日期：2005-08-01 00:00:00

abstract：:Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

journal_title：Journal of neuroimmunology

authors： Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

更新日期：2005-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The iron-chelator desferrioxamine (DFX) increased the expression of hypoxia-inducible factor (HIF)-1alpha in the hair cell line, HEI-OC1. The increased VEGF production by DFX was inhibited by iron. DFX also induced the activation of mitogen-...

journal_title：Journal of neuroimmunology

authors： Jeong HJ,Kim JB,Hong SH,An NH,Kim MS,Park BR,Park RK,Kim HM

更新日期：2005-06-01 00:00:00

abstract：:The aim of the present study was to define the cellular composition of ventricular, as compared with lumbar, cerebrospinal fluid (CSF) in patients with non-inflammatory neurological disorders (NIND). We addressed this issue by determining the cellular composition of lumbar CSF from patients with normal pressure hydroc...

journal_title：Journal of neuroimmunology

authors： Provencio JJ,Kivisäkk P,Tucky BH,Luciano MG,Ransohoff RM

更新日期：2005-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease associated with environmental factors, possibly including several viruses such as the coronaviruses. Indeed, murine coronavirus (MHV) infection provides a well-known experimental model for MS studies. Intracerebral infection of C57BL/6 mice with MHV-A59 revealed that vi...

journal_title：Journal of neuroimmunology

authors： Gruslin E,Moisan S,St-Pierre Y,Desforges M,Talbot PJ

更新日期：2005-05-01 00:00:00

abstract：:15% of myasthenia gravis (MG) patients do not have antibodies against the acetylcholine receptor (AChR). Some of these "seronegative" MG patients have antibodies against muscle specific kinase (MuSK), and many have a non-IgG factor that acutely inhibits AChR function in a muscle-like cell line, CN21. Here we show, usi...

journal_title：Journal of neuroimmunology

authors： Spreadbury I,Kishore U,Beeson D,Vincent A

更新日期：2005-05-01 00:00:00

abstract：:Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in...

journal_title：Journal of neuroimmunology

authors： Kato S,Tsuzuki Y,Hokari R,Okada Y,Miyazaki J,Matsuzaki K,Iwai A,Kawaguchi A,Nagao S,Itoh K,Suzuki H,Nabeshima T,Miura S

更新日期：2005-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study ai...

journal_title：Journal of neuroimmunology

authors： Storer PD,Xu J,Chavis J,Drew PD

更新日期：2005-04-01 00:00:00

abstract：:We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The m...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Miyagishi R,Ochi H,Nakamura I,Niino M,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2005-04-01 00:00:00

abstract：:The aim of this study was to investigate whether chronic stress, induced by repeated daily swimming during 21 days, alters the morphofunctional parameters in the thymus of adult rats. Our results showed that chronic stress reduced thymus mass, total number of thymocytes, volume of the thymus compartments and numerical...

journal_title：Journal of neuroimmunology

authors： Zivković IP,Rakin AK,Petrović-Djergović DM,Kosec DJ,Mićić MV

更新日期：2005-03-01 00:00:00

abstract：:To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid ...

journal_title：Journal of neuroimmunology

authors： van der Flier M,Coenjaerts FE,Mwinzi PN,Rijkers E,Ruyken M,Scharringa J,Kimpen JL,Hoepelman AI,Geelen SP

更新日期：2005-03-01 00:00:00

abstract：:Serotonin transporter sites were characterized in blood lymphocytes of rats. Pharmacological characteristics of drug interactions were in concordance with recent studies in nervous and human immune cells. The potency order of inhibition of [(3)H]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. Selec...

journal_title：Journal of neuroimmunology

authors： Cedeño N,Urbina M,Obregón F,Lima L

更新日期：2005-02-01 00:00:00

abstract：:Interleukin (IL)-10 is an anti-inflammatory cytokine that can down-regulate various aspects of the immune response. In this study we demonstrate that exposure to a psychophysiological stressor (swim stress) increases IL-10 production in female rats in response to an in vivo challenge with bacterial lipopolysaccharide ...

journal_title：Journal of neuroimmunology

authors： Connor TJ,Brewer C,Kelly JP,Harkin A

更新日期：2005-02-01 00:00:00

abstract：:We analyzed the relationship between the expression of interferon (IFN)-gamma and HTLV-I p19 antigen and activation of p38 mitogen-activated protein kinase (p38 MAPK) in two HTLV-I-infected T cell lines derived from two patients (HCT-1 and HCT-4) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...

journal_title：Journal of neuroimmunology

authors： Fukushima N,Nishiura Y,Nakamura T,Yamada Y,Kohno S,Eguchi K

更新日期：2005-02-01 00:00:00

abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

journal_title：Journal of neuroimmunology

authors： Marra S,Burnett M,Hoffman-Goetz L

更新日期：2005-01-01 00:00:00

abstract：:Neutrophil activity was elevated in the conditioned mice for the first time through an established conditioned training process. Catecholamines were proved to be important in the regulation of this conditioned innate immunity. In the study, the camphor odor (as the conditioned stimulus, CS) and poly I: C (as the uncon...

journal_title：Journal of neuroimmunology

authors： Chao HJ,Hsu YC,Yuan HP,Jiang HS,Hsueh CM

更新日期：2005-01-01 00:00:00

abstract：:Dendritic cells are the critical mediators of various immune responses and are the first line of defense against any infection including HIV. They play a major role in harboring HIV and the subsequent infection of T cells and passage of virus through the blood-brain barrier (BBB). The recently discovered DC-specific, ...

journal_title：Journal of neuroimmunology

authors： Nair MP,Schwartz SA,Mahajan SD,Tsiao C,Chawda RP,Whitney R,Don Sykes BB,Hewitt R

更新日期：2004-12-01 00:00:00

abstract：:The urokinase plasminogen activator (uPA) and its receptor (uPAR) play important physiological functions in extracellular proteolysis, as well as cell adhesion and migration. Through dysregulation of these functions, the uPA/uPAR system might be involved in the pathogenesis of AIDS dementia complex (ADC), and, in fact...

journal_title：Journal of neuroimmunology

authors： Sidenius N,Nebuloni M,Sala S,Zerbi P,Price RW,Gisslen M,Hagberg L,Vago L,Lazzarin A,Blasi F,Cinque P

更新日期：2004-12-01 00:00:00

abstract：:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

journal_title：Journal of neuroimmunology

authors： McCue D,Ryan KR,Wraith DC,Anderton SM

更新日期：2004-11-01 00:00:00